Tottenham Hotspur will look to tighten their grip on second against Europa League-chasing Southampton, before Manchester City host Arsenal with a place in the Champions League at stake. Liverpool also take on Watford.
Meanwhile, it's the penultimate day of the season in La Liga, with Barcelona, Atletico Madrid and Real Madrid all battling for top spot.
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13': Game has started with electrifying pace and Arsenal seem to have finally squashed the initial Man City onslaught.
Lionel Messi has now scored 26 goals in 32 La Liga matches in 2015/16.