Defeat for Manchester United in Sunday's clash with Tottenham would not only all-but end their slim title hopes, their chances of finishing in the top four would be in serious jeopardy.
Losing to Mauricio Pochettino's men would send Jose Mourinho's side nine points adrift of Spurs, who will start the game fifth.
Elsewhere, rampant Chelsea host high-flying West Brom while troubled West Ham, hammered 5-1 against Arsenal last week, visit Anfield with Liverpool still reeling from last Sunday's incredible 4-3 defeat at Bournemouth.
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MAN UNITED: Manchester United, heading into their home match against Tottenham, have drawn six of their last eight league matches, with their visitors having drawn four in the same period.