The Europa League returns with the quarter-final second leg ties scheduled to be played on Thursday.
Manchester United will fancy their chances of progressing to the last four as they hold a two-goal advantage over Granada.
However, Harry Maguire, Luke Shaw and Scott McTominay all miss the game through suspension.
Arsenal will be without David Luiz and Kieran Tierney for their tough trip to face Slavia Prague.
The two sides are locked at 1-1 after the first game, leaving the Gunners needing to score at least once to reach the semi-finals.
Roma are a good bet to go through to the next round after securing a 2-1 lead over Ajax in Amsterdam last week.