Liverpool and Arsenal clash in an early six-pointer chasing the Premier League title, with one or both of the joint-leaders set to drop points for the first time this term in Week 3.
The two giants will meet at Anfield in Saturday's late kick-off, before which Manchester United host Crystal Palace hoping to get back to winning ways after they drew 1-1 at Wolverhampton Wanderers on Monday.
Aston Villa open Week 3 at home to Everton on Friday evening, while Chelsea travel to Norwich City in Saturday's early fixture pursuing their first competitive win under Frank Lampard.