Liverpool's Merseyside derby with Everton and Jose Mourinho's first game against former club Manchester United highlight the midweek fixtures in the Premier League.
Manchester City begin things on Tuesday with a difficult trip to Turf Moor to take on Burnley. The Citizens' title hopes are hanging by a thread after Saturday's 2-2 draw away to Newcastle United, but the creativity of David Silva and Bernardo Silva can see them to a vital win.
Liverpool own an 11-point cushion over City, and the leaders can take advantage of their struggling neighbours and maintain their lengthy unbeaten run in England's top flight, provided Virgil van Dijk is on form at the back.