Premier League leaders Chelsea take on London rivals Tottenham Hotspur at Stamford Bridge in the headline match of Week 13 on Saturday.
With Liverpool and Manchester City, who play Sunderland and Burnley, respectively, just one point behind the Blues in the standings, Chelsea will be desperate to claim all three points to ensure they remain top of the pile.
Meanwhile, fourth-placed Arsenal host Bournemouth on Sunday, while Manchester United take on out-of-form West Ham United at Old Trafford.
Read on for a closer examination of some of the key players to look out out for over the weekend's action, along with a full fixture list and predictions.