Arsenal have brought in Mohamed Elneny against Tottenham while goalkeeper David Ospina comes in to replace the injured Petr Cech.
The Gunners are without centre-back Laurent Koscielny (calf) and are also missing midfielders Jack Wilshere (leg), Tomas Rosicky (thigh), Santi Cazorla (knee) and Alex Oxlade-Chamberlain (knee).
Gabriel comes in for Koscielny in defence, while Danny Welbeck takes his place up front with Theo Walcott dropped to the bench after a poor showing against Swansea and Olivier Giroud also left out.