The Red Devils may have taken a tumble in the standings this year, but they have been tipped to end the Spaniards' record reign in 12 months.
Real Madrid has been named as the richest club in the world for the 11th successive season, while Manchester United has fallen from second to third, with Barcelona taking its place.
Paris Saint-Germain has leapfrogged Bayern Munich into fourth, while nine Premier League outfits find themselves in the top 20, highlighting the financial clout of the English top flight.
The Deloitte Money League 2016, published on Thursday in Europe, reports that these elite sides generated over 5 billion pounds ($7.