Deportivo Tachira secured a 1-0 advantage over Pumas UNAM, while Atletico Nacional kept Huracan scoreless.
A second-half strike from Yuber Mosquera saw Deportivo Tachira claim a 1-0 win over 10-man Pumas UNAM in the Copa Libertadores round-of-16 first leg.
Following a scoreless first half, Mosquera opened the scoring at the Estadio Polideportivo de Pueblo Nuevo in the 50th minute Tuesday.
Carlos Cermeno put in a dangerous cross and Mosquera was on hand to guide the ball past Pumas goalkeeper Alejandro Palacios to give the Venezuelans the advantage.
But Mosquera was lucky to still be on the pitch following a high boot on Alejandro Castro in the first half, which left the Mexican with a big mark on his chest.