Nacional is into the Copa Libertadores quarterfinals, but defending champion River Plate suffered a last-16 exit.
Nacional advanced to the quarterfinals of the Copa Libertadores following a drama-filled 2-2 draw at Corinthians on Wednesday.
The Uruguayan side, which was held to a scoreless draw in the first leg, led twice at the Arena Corinthians but was pegged back on both occasions, though it was enough to see Nacional progress on away goals.
Nicolas Lopez kept up his great goal-scoring form to open proceedings inside five minutes before Corinthians equalized 10 minutes later through winger Lucca.
Nacional restored its lead 12 minutes into the second half thanks to Santiago Romero's strike, but a thrilling finale saw Corinthians given two opportunities to score from the penalty spot.