An away goal from Jose Angulo saw Independiente del Valle qualify for the Copa Libertadores group stage, while Santa Fe also made it through.
Independiente del Valle booked its spot in the group stage of the Copa Libertadores despite a 2-1 loss to Guarani.
The Ecuadorian outfit travelled to Guarani with a 1-0 lead from last week's first leg and was on track to progress with Thursday's contest scoreless at halftime. But a 62nd-minute effort from Guarani's Marcelo Palau levelled the tie on aggregate, leaving Independiente's progression in doubt.
Jose Angulo scored the all-important equalizer and away goal 14 minutes from time to put Independiente 2-1 up on aggregate.