Holders Barcelona thrashed Espanyol in the first leg of the Copa del Rey round of 16. Manager Gary Neville's Valencia also did the same to Granada, while last season's beaten finalists, Athletic Bilbao, scraped past Villarreal.
It was something of a derby day in the Spanish cup with Barca embroiled in a Catalan derby, while Seville's main rivals also locked horns.
Here are the full results from Wednesday's round-of-16 first-leg matches:
| Home | Score | Away |
| Athletic Bilbao | 3-2 | Villarreal |
| Mirandes | 1-1 | Deportivo La Coruna |
| Valencia | 4-0 | Granada |
| Real Betis Balompie | 0-2 | Sevilla |
| Barcelona | 4-1 | Espanyol |
| Rayo Vallecano | Atletico Madrid |
Recap
Barca were stung by their Catalan neighbours early on at the Camp Nou.