Chelsea aim to keep up the pressure on Manchester City and Liverpool when they take on Crystal Palace at Stamford Bridge.
If the Blues win and Southampton pull off a shock result against City in the 3pm GMT (10am ET) kick off, Chelsea will find themselves top of the Premier League.
Even if City do beat the Saints, the west Londoners will still leapfrog Liverpool on goal difference with a win today.
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Palace on the other hand are aiming to put further distance between themselves and the relegation zone, and will take confidence from their 2-2 draw with Arsenal last weekend.