Barcelona have already booked their spot in the last 16 of the 2018-19 UEFA Champions League, and they could be joined by the likes of Atletico Madrid, Borussia Dortmund and Inter Milan on Wednesday.
Group D is also on the verge of being sewn up with a matchday to spare. All Porto need is a draw to guarantee progress, and a point would also be a decent result for Schalke at the Estadio do Dragao.
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The tightest group in the competition is Group C, where Paris Saint-Germain, Liverpool, Napoli and Red star Belgrade can all still qualify for the knockout rounds depending on their final two results.