Caf Champions League holders Esperance were eliminated by Zamalek in Friday's quarter-final second leg despite winning 1-0 on the night at the Stade Olympique de Rades.
The Tunis outfit lost the first leg in Egypt 3-1 and needed to win the reverse fixture 2-0, or by three goals or more to progress to the semi-final.
However, they exited the competition on Friday 3-2 on aggregate after failing to overturn the first-leg deficit.
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Moine Chaabani’s side started well and were rewarded for their bright start when Billel Bensaha converted a fifth-minute penalty to send the hosts into an early lead.