The midfielder has been confirmed as the latest new arrival in what is proving to be a very busy summer transfer window for the Turkish giant.
Brazil international Souza is set to join Fenerbahce in a 8 million euro switch from Sao Paulo.
The 26-year-old midfielder was drafted into the Selecao squad following last year’s World Cup but failed to make coach Dunga’s squad for the Copa America.
On Thursday, Sao Paulo confirmed that the player would miss its next league clash after the club agreed his sale to the Turkish giant pending medical clearance.