Kaizer Chiefs travel to Tshwane to take on Bloemfontein Celtic for their 25th league match of the season.
Ernst Middendorp's men could move nine points clear of second-placed Mamelodi Sundowns with a win over Phunya Sele Sele.
However, after having made to work extra hard to seal victory in the first round, Amakhosi know they cannot underestimate Celtic.
Editors' Picks
The last match between the two sides was an eight-goal thriller with the Glamour Boys bagging all three points at the end of the match.
TV Channel, Live Score & How To Watch
The game will be shown live on SuperSport 4.