Unzue has made six changes to the side that drew against Real at the weekend. Sergio Alvarez starts in goal, while Sergi Gomez and Fontas come into the backline. Stanislav Lobotka and Jovabad Sanchez start in the middle of the park, while Emre Mor replaces Maxi Gomez leading the line alongside Iago Aspas.
Lionel Messi, Andres Iniesta and Luis Suarez were rested for the first leg of the tie, but Valverde recalls his big guns for the second leg. Jasper Cillessen returns between the sticks after taking his place back on the bench against Levante. Javier Mascherano and Nelson Semedo start in the back four after missing out at the weekend.