The Catalans, who are on a 34-game unbeaten run, will host their fierce rival at Camp Nou on April 2, with Madrid looking for revenge after the 4-0 reverse back in November 2015.
The date for the second Clasico between Barcelona and Real Madrid this season has been announced.
The two Liga rivals will face off at Camp Nou on April 2 as the Blancos look to get revenge for the 4-0 defeat they suffered in November.
Two goals from Luis Suarez and one each from Neymar and Andres Iniesta ensured the Catalans smashed then-manager Rafael Benitez's side at the Bernabeu, with Isco shown a red card late on in the contest.