Rafinha could return from over eight months out in Saturday's Clasico between Real Madrid and Barcelona.
The midfielder has undergone knee surgery twice in 2017 after injuring the internal meniscus in his right knee against Granada in April.
Rafinha returned to first-team training this month and Barcelona confirmed on Monday that the 24-year-old has been given the medical all-clear.
While unlikely to start against Madrid in Saturday's first LaLiga Clasico of the season, Rafinha could at least earn a place on the bench, with head coach Ernesto Valverde facing other injury concerns.
Barca will be without Paco Alcacer after the forward was injured in Sunday's 4-0 thrashing of Deportivo La Coruna.