Barcelona have announced that Sergino Dest and Ousmane Dembele are both sidelined after picking up injuries.
The news is yet another blow for the Catalan giants who have been plagued by injuries to key players throughout the early weeks of the season.
Dembele is out once again despite only just making his return from knee surgery. The Frenchman played 25 minutes against Dynamo Kiev but now has a hamstring problem.
Dest did not feature in Ukraine and interim coach Sergi Barjuan admitted after the match the USMNT star dropped out late because of a knock.