Barcelona fear Ronald Araujo suffered a sprained ankle against Sevilla on Sunday and will be out of action for around three weeks.
The Uruguay international was forced off midway through the first half of the game after appearing to pick up the issue following a hefty challenge from Saul.
Araujo was spotted on the bench with an ice pack on his ankle and will now undergo further tests on the injury.
According to AS, the early prognosis is that Araujo has suffered a sprain and will now be out for around three weeks.