Tottenham Hotspur will look to tighten their grip on second against Europa League-chasing Southampton, before Manchester City host Arsenal with a place in the Champions League at stake. Liverpool also take on Watford.
Meanwhile, it's the penultimate day of the season in La Liga, with Barcelona, Atletico Madrid and Real Madrid all battling for top spot.
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REVIEW: Huge result for Manchester United, more than anyone. If they can beat Bournemouth and West Ham, then they'll secure fourth spot and Champions League football for next season.