Albiceleste coach Edgardo Bauza has selected the Barcelona star for the key clash in Mendoza, while Paulo Dybala, Lucas Pratto and Angel Di Maria also feature.
Lionel Messi will make his international return against Uruguay in a World Cup qualifier on Thursday after recovering from a hamstring injury in time, the Argentine Football Association has confirmed.
Messi announced his retirement from international football in June after having a penalty saved in the shoot-out of the Copa America final against Chile, with Argentina losing the final for the second year in a row to the same opposition.
But Messi's retirement only lasted until August as he quickly reversed his decision and returned to the fold, with new Argentina coach Edgardo Bauza naming the Barcelona forward in his first team for the clash in Mendoza.