Barcelona suffered a late blow at Los Carmenes after losing Ronald Araujo to an injury picked up in the warm-up.
The Uruguay international was named in the starting XI alongside Oscar Mingueza but had to miss out after picking up a knock ahead of kick-off.
Barcelona were already without Clement Lenglet due to suspension meaning Samuel Umtiti was drafted in for his first start of the season.
Umtiti had looked set to miss out with Mingueza preferred as the replacement for Lenglet but Araujo’s injury means he does have a chance to try and impress coach Ronald Koeman against Granada.