The Tigres winger will not travel to Florida with El Tri for Wednesday's friendly with Senegal after suffering an injury with his club.
Mexico is traveling to Florida with just 21 players after Javier Aquino stayed behind with a hamstring injury.
The Tigres winger was substituted from Friday's win against Chiapas, and the Mexican federation announced Sunday that he would not be part of Juan Carlos Osorio's squad to face Senegal on Wednesday after initially receiving a call-up.
"During the match with his club, he had muscular discomfort in the his left hamstring and he was substituted," a statement released by the federation.