In the first competitive fixture since the Blaugrana defeated Alaves in the Copa del Rey final, the two sides will do battle at the Mendizorrotza Stadium in the second round of games in La Liga.
The visitors will be hoping to put all the negative energy surrounding the team behind them, while keeping the pace with rivals Real Madrid, who started the season with a comfortable 3-0 victory last weekend.
Hosts Alaves started the season with a 1-0 defeat away to Leganes, so will be hoping for a better performance against the likes of Lionel Messi.
Classic Encounter
Look no further than last season's Spanish Cup final, where five time Champions League winners Barcelona defeated the Babazorros in a great match - with a professional performance from talisman Messi ending coach Luis Enrique's final game with the only trophy of their season.