Barcelona could wrap up La Liga's title in Week 34 and travel to Alaves on Tuesday knowing three more points could be enough to guarantee them a second successive league crown.
Atletico Madrid sit nine points behind with five games remaining in their season. They'll only be able to finish level on points with Barca if the Blaugrana defeat Alaves while they lose at home to Valencia on Wednesday, and Atleti's head-to-head record leaves them at a disadvantage in that case.
Alaves are eighth in La Liga and could temporarily move up to seventh with a result, though they've lost in each of Barca's last four visits to the Mendizorrotza Stadium.