Barcelona have been struggling in recent weeks, and the loss to Real Betis was a shining example of players struggling to cope with the unforgiving schedule of club and international football.
Players like Sergio Busquets, Ivan Rakitic, Luis Suarez, and Philippe Coutinho are starters for Barcelona and their respective international teams, but are rarely ever given the opportunity to rest. Of the mentioned names, only Philippe Coutinho has been rotated regularly, and that has less to do with the coach and more to do with the fact that the Brazilian has failed to complete 90 minutes of high-octane football without showing signs of fatigue.