Week 1 is only 1/17th of the NFL regular season, but it naturally feels more important. Rookie players and coaches make their real debuts after briefly checking in during the preseason. Free-agent and trade acquisitions show what they can do in their new cities. A big game in Week 1 just seems more meaningful than it does in Week 11. A disastrous one has the opposite effect.
Those games don't really mean anything more. Go back to Week 1 of 2018 and you'll see the Jets dropping 48 points on the Lions, and the Buccaneers doing the same in a 48-40 win over the Saints.