49ers 28, Seahawks 17. This is a real prove-it game for both teams. The NFL world is now accepting the 49ers as for real, while pointing out that San Francisco has beaten only two teams that currently have winning records (the Rams and Carolina, but having done so in impressive fashion, by a combined 51 points). Seattle likewise has gotten to 7-2 beating only one team that currently has a winning record (the Rams in a last-second thriller). What might be the most raucous home-field edge the 49ers have had since moving to Santa Clara in 2014 will help SF draw first blood in the battle for the NFC West.