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Monday Night Football is set to feature a pivotal early season divisional matchup for the San Francisco 49ers (-4.5)
(-1.5) and the visiting Los Angeles Rams (-4.5) (+1.5). In spite of the fact that the Niners are 1-2 and the Rams are 2-1, both are 1-0 in divisional play and San Francisco will open as slight favorites at home, with DraftKings Sportsbook giving them a 1.