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This week's NFL action kicks off with the San Francisco 49ers visiting the Seattle Seahawks on "Thursday Night Football" (8:15 p.m. ET, Prime Video).
Despite their 2-3 start, the 49ers remain the odds-on favorite to win the NFC West (-115) ahead of the Seahawks (+225), who sit atop the division at 3-2.
San Francisco has the best of odds of any NFC team to win the Super Bowl (+750), tied for second with the Baltimore Ravens and trailing only the reigning champion Kansas City Chiefs (+450).