Gattis launched a two-run home run a projected 426 feet, Josh Reddick ripped an RBI single to left and Jose Altuve walked with the bases loaded in the ninth to tack on four more insurance runs.
Houston starting pitcher Francis Martes, who filled in for Brad Peacock (paternity list), lasted only two innings and allowed two runs on two hits, with four walks and three strikeouts. But Michael Feliz, Chris Devenski, Will Harris and Luke Gregerson combined to blank the Mariners the rest of the way.