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College football Week 4: Florida-Tennessee, Clemson-Wake Forest highlight the biggest games

College football's last weekend in September is officially here, meaning conference rivalries move to the forefront of Saturday's slate.

Sure, we'll miss the nonconference battles like Appalachian State upsetting Texas A&M in College Station or Georgia proving why the title still runs through Athens, but conference play is where seasons are defined.

Saturday's schedule kicks off with some historic matchups and newfound rivalries. Wake Forest welcomes Clemson to town in what should be a litmus test for the program while Ohio State hosts Wisconsin in an age-old rivalry that has been a little one-sided of late.

Speaking of recent lopsided rivalries, Florida travels to Tennessee, where the Vols are favored despite their ineptitude in the SEC East clash over the past couple of decades.