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Will the 49ers run defense hold up against the Cardinals?

The San Francisco 49ers are staying home in Week 5 when they face off against the Arizona Cardinals at Levi’s Stadium, looking to build off their 30-13 over the New England Patriots last weekend.

The Cardinals are coming off a rough 42-14 defeat to the Washington Commanders, where defensive struggles and inefficiencies in the passing game took away any chance of success.

But, one area where they continued to excel was the running game, as James Conner hit the 100-yard threshold, while the Cardinals went for 181 yards and a touchdown on 5.