The San Francisco 49ers are currently one of six teams with either 2 or 3 wins after the Detroit Lions broke out of their funk to extend their winning streak to three games. The other teams with three wins are the Baltimore Ravens, who will be without Joe Flacco for the rest of the season, and the Dallas Cowboys, who will be without Tony Romo for the remainder of the year.
So, yes, all three one win teams are without their starting quarterbacks for the final stretch of the 2015 season.