Even though the 49ers play Arizona twice in 22 days, things may be very different in Sunday’s rematch. The Cardinals fired OC Mike McCoy a week ago, and former QB Byron Leftwich will call his first game as their new offensive coordinator Sunday.
So can we expect a radically different offense? No, we can’t. The plays and formations have all been installed for months. You can’t start all over mid-season, especially not with a rookie starting at quarterback.
For that matter, Leftwich is pretty green himself (as a coach anyway; he was an NFL QB for 9 years, 2003-2012).