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What are the biggest uncertainties for the 49ers heading into Week 1?

The San Francisco 49ers are a full-go ahead of Week 1 with their core players back, as Trent Williams and Brandon Aiyuk are both back at practice ahead of their Monday Night Football contest against the New York Jets.

After a months-long negotiation with both players, it’s a good sign that both players are back in the fold for a full week of preparation with the team, as the 49ers definitely missed both players throughout training camp.

But, as the team prepares for Week 1, are there any remaining uncertainties for head coach Kyle Shanahan?