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The 49ers lost the fourth most games to injury according to Football Outsiders in 2018

Football Outsiders has a yearly offseason article where they recap the injuries from the prior NFL season. The term they use is Adjusted Games Lost, which is described as:

Adjusted Games Lost (AGL): Measurement of the cost of injuries, both in terms of missed games and games where players were not able to play to their full potential. Estimates a number of games based on whether players are listed as Probable, Questionable, Doubtful, or Out. Introduced in Pro Football Prospectus 2008 essay, “The Injury Effect.”

Like one possession games, health, turnover differential, and a handful of other stats, adjusted games lost fluctuates from year-to-year.