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The 49ers could face an unexpected challenge from the Browns in this area

Fresh off a 42-10 victory over the Dallas Cowboys, the San Francisco 49ers are facing off against the Cleveland Browns on the road in Week 6, looking to remain undefeated on the season.

Heading into the game, the 49ers are seen as seven-point favorites over the Browns, who may be without Deshaun Watson for the second consecutive week, as the quarterback has missed consecutive practices while ailing from a shoulder injury.

The line continues to shift in favor of the 49ers as Watson misses time, leading many to speculate that San Francisco could have an easy matchup against the Browns, especially after they were shellacked 28-3 by the Baltimore Ravens in Week 5 with backup quarterback Dorian Thompson-Robinson earning the start.