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The 49ers could be without 60 percent of their offensive production from 2023 on Sunday

The average commercial to advertise a 49ers/Rams game would include highlights of players like Deebo Samuel, Christian McCaffrey, Cooper Kupp, and Puka Nacua.

Unfortunately, instead of a list of players in a highlight reel, it’s an injury list for the first of two 2024 meetings between the two division rivals. Potentially six Week 1 starters combined - seven if Christian McCaffrey is included - will miss Sunday’s Week 3 clash. The 49ers will be without Samuel and McCaffrey, with George Kittle missing practice on Thursday, and Los Angeles missing Nacua, Kupp, Jonah Jackson, and Steve Aliva from its offense.