With Anthony Davis' retirement and the Andy Lee trade, the San Francisco 49ers are continuing a radical and dramatic overhaul of their roster. As it stands at the moment, only 16 players on the roster predate the 2013 offseason:
- Vernon Davis, the longest-tenured 49er now that Andy Lee has retired, was taken with the sixth overall pick in the 2006 draft.
- Joe Staley was taken with the 28th overall pick in the 2007 draft.
- Ahmad Brooks was picked up off waivers from Cincinnati in 2008.