The 49ers are home dogs to start the season.
The NFL schedule was released Thursday evening, and the San Francisco 49ers will open the 2016 season at home against the Los Angeles Rams September 12, on Monday Night Football. Although we are still two weeks away from the NFL Draft, we already have a spread for Week 1.
The LV SuperBook released preliminary lines shortly after the schedule release. The 49ers have opened as a 2.5-point underdog against the Rams. That line will likely change plenty between now and September 12, but we at least have some early context.