are on the road to face the Indianapolis Colts (+16.5) on Monday Night Football. Jeff Saturday is coming off an epic collapse against the Vikings. Indy will be without star running back Johnathon Taylor and will have a new quarterback under center.
Nick Foles makes his debut for the Colts. They have a chance to play spoiler, as the Chargers can clinch a playoff berth with a win. Los Angeles has gotten healthier and should be close to full strength.
The Chargers are 3.5-point favorites, with the total on the game set at 44.