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Instant reaction to the 49ers 40-34 loss to the Detroit Lions: Many changes are needed in 2025

The San Francisco 49ers suffered a 40-34 loss to the Detroit Lions on Monday night in a game that was much of the same for the Niners once again.

It was a strong offensive start for San Francisco, who scored touchdowns on each of their first three drives, but faltered in the second half with costly interceptions.

Defensively, the 49ers allowed 40 points for the first time this season, as Nick Sorensen’s unit got just one stop all game long, which came on a turnover on downs at the San Francisco eight-yard line.