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49ers vs. Bills preview on Sunday Night Football: Will the San Francisco 49ers be able to pull off the upset against the Buffalo Bills on the NFL week 13 schedule? We're discussing 49ers news, 49ers injury news, 49ers rumors, 49ers vs. Bills keys to the game, 49ers vs Bills matchups to watch, 49ers vs. Bills betting odds, Brock Purdy injury, Kyle Shanahan, Christian Mc
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