The San Francisco 49ers head on the road for this first time this season to meet the Pittsburgh Steelers in a clash of marquee Super Bowl era franchises.
The 49ers are on a short week after playing on Monday night while the Steelers have a few extra days' rest following their Thursday opener.
Here are the experts' picks from around the web for the Week 2 matchup. Give us your predictions in the comment section below...
Don Banks of Sports Illustrated: Steelers 29, 49ers 23
"I took my medicine and offered a mea culpa to 49ers fans via Twitter, after pronouncing that their favorite team would start the year 0–8 in my 20 bold predictions column this preseason.