The San Francisco 49ers managed to win in Houston but there were still some challenges on the field, and one of them was Texans wide receiver DeAndre Hopkins. It should be noted that Hopkins has the second most receiving yards (1,233 yards) in the league after Week 14, behind Antonio Brown.
Hopkins dissected the 49ers defense, finishing the day with 11 receptions for 149 yards and two touchdowns. The defensive back who spent most of the day with the challenging task of covering Hopkins was Dontae Johnson. Midway through the third quarter after one defensive holding call and two defensive pass interference calls, Greg Mabin replaced Johnson and defensive coordinator Robert Saleh adjusted the coverage a bit.