Chip Kelly uses a third wide receiver a lot more than we've seen the 49ers do in recent seasons. This could mean Carlos Hyde gets a chance to face more nickel defenses.
The San Francisco 49ers will see an overhaul to their offense this season, as Chip Kelly looks to revitalize a unit that was pretty awful in 2015. Kelly has said it will be somewhat like what he has done in the past, and you can learn more about that in David Neumann's extensive Eagles film breakdown.
Assuming Chip Kelly provides some continuation from his previous offenses, one thing we can expect to see is the offense facing more nickel defenses.